Ibuprofen, on the other hand, should be used cautiously by individuals with heart disease, high blood pressure, clotting disorders, kidney problems and the elderly. Some feel acetaminophen works better for them, whereas others find ibuprofen better relieves a headache. She says to talk to your UnityPoint Health provider before taking either acetaminophen or ibuprofen regularly. Reeder describes the uses, benefits and potential problems with these as well: Naproxen. It can also cause painful and bleeding ulcers in the stomach. While most people have no issue taking the appropriate doses of acetaminophen or ibuprofen, Reeder says there are situations where you should be extremely cautious. The Top 8 Respiratory Illnesses and Diseases. Ibuprofen may be used once children are over 6 months of age.