Therefore, the objective of this study was to assess the knowledge and practice of menstrual hygiene among high school girls at Nekemte town, Oromia region, Western Ethiopia. BMC Women's Health 15, 84 Five hundred twenty seven Data were cleaned and entered into a computer using Epi-info Window version 3. All authors read and approved the final manuscript. The reason could be that educated mothers may provide information about menstruation and menstrual hygiene to their daughters. Basically, the study addressed the sensitive issue about menstrual hygiene and the possibility of social desirability bias is unavoidable even if we have tried our best to minimize it.